Wild quinine (Parthenium integrifolium) is a native perennial herb in the Asteraceae family, found in the eastern and central United States. It forms sturdy stems, rough leaves, and flat-topped clusters of small white flowers, and both the root and aerial parts have a history of traditional use.

Traditionally, wild quinine was used in Native American and early American herbal practice, especially in preparations linked with digestive support and topical use. Today it is also appreciated as a prairie wildflower and beneficial pollinator plant in naturalistic landscapes.